Simvastatin STADA 5 mg film-coated tablets

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Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Area of application

All fields of application by the manufacturer

Application to this, the 5 mg film-coated tablets in combination with simvastatin STADA area there is more detailed information:

• Lipid metabolism

Variant comparison

Simvastatin STADA 5 mg film-coated tablets are available in the following variants:
(Please note also our notes about the price and payment information)

Variant comparison
-Ad-
Pack size and dosage form	Potency (dosage per film-coated tablet)	Cheapest price per Pack (with surcharge),(Versandkosten)
100 Film-coated tablets	5 Milligrams of simvastatin	14,60 EUR (5.00 EUR), price (3,95 EUR shipping) price comparison
50 Film-coated tablets	5 Milligrams of simvastatin	Price 11,92 EUR (5.00 EUR), (3,95 EUR shipping) price comparison
30 Film-coated tablets	5 Milligrams of simvastatin	10,94 EUR (0,00 EUR), price (3,95 EUR shipping) price comparison

• Similar drugs

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Other components

The following substance not effective components are part of the drug:

• Hyprolose
• Hypromellose
• Magnesium stearate
• mikrokrist. Cellulose
• Talcum powder
• Titanium dioxide (E 171)
• Butylated (E 320)
• Eisen(III)-hydroxid-OXID×H2O (E 172)
• Lactose 1-water
• vorverkl. Corn starch

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

So does simvastatin STADA 5 mg film-coated tablets

Simvastatin STADA 5 mg film-coated tablets contain the active ingredient simvastatin. Learn more about the applications and the effect of simvastatin below. Read also the information about the active group of statins, to which belongs the active ingredient simvastatin.

Fields of application of the active substance: simvastatin

Simvastatin is used to reduce elevated cholesterol values in the blood, if a low fat and low-cholesterol diet, a weight loss and physical training of improvement are not enough. Simvastatin causes a drop of “bad” LDL cholesterol and a relative increase of vascular protective HDL cholesterol. The administered dose of active ingredient is typically between five milligrams to 40 milligrams once a day, depending on, how much the LDL cholesterol should be reduced.

Is the concentration of cholesterol in the blood is lowered by simvastatin, it can accumulate any more in the form of so-called plaques in the blood vessels. In this way, the active ingredient protects against changes and hardening of the blood vessel walls (arterial circulatory disorders), as well as heart attack or stroke.

After vascular replacement heart (bypass surgery), the new blood vessels, especially in high-risk patients can clog quickly. Such patients include those who to diabetes (diabetes mellitus) or are suffering from a disease of the coronary vessels, or already had a heart attack. Simvastatin can help to keep open the bypass. To prevent an active ingredient quantity of 20 to 40 milligrams of simvastatin, is captured each in the evening.

A hereditary conditional increase of well-controlled-Gehalts (Hyperlipidemia type IIa, IIb and IV to common medical Division) simvastatin is used in addition to a diet, if the diet alone causes no sufficient reduction of blood lipids. The active ingredient is taken up this once in the evening in the amount of 40 milligrams. An active ingredient quantity of 80 milligrams of simvastatin (taking 20 mg morning, 20 mg at noon and 40 mg at night) is only used for very severe increase in the blood lipids (severe hypercholesterolemia) or very high risk for a closure of the coronary vessels. With an effective entrance is to be expected two weeks after starting treatment. In coronary artery disease, the treatment should be maintained to at least over a year.

Following applications of simvastatin, more detailed information are available:

• Lipid metabolism
• Stroke
• Heart attack
• Diabetes mellitus type 2
• Diabetes mellitus type 1
• Heart and cardiovascular problems

Effect of simvastatin

Simvastatin is one of the active group of statins. It is used for the reduction of elevated cholesterol values in blood and prevent vascular deposits at the same time. This reduce the risk for stroke and heart attack.

Simvastatin effect primarily in the liver, where the blood lipids and among them also the cholesterol, are produced. Cholesterol is transported in various forms in the blood, bound to proteins of low density (as LDL cholesterol) or proteins of high-density (HDL cholesterol). From the form of LDL can easily dissolve the cholesterol and deposited on the walls of the blood vessels. This form is therefore especially dangerous. The HDL form, however, can resume even mounted off cholesterol and thus reduce deposits. It is in this way protecting on the vessels.

Simvastatin effect on the forms of transport of cholesterol differently. It lowers blood levels of “bad” LDL cholesterol by more than 45 per cent and can provide the “good” because tank protective HDL cholesterol by 15 percent increase. This improves the ratio of lipids to each other. This can be done both increased Cholesterinspiegeln and normal Cholesterinspiegeln.

Simvastatin reached its maximum concentration in the blood quickly, after about one or two hours. A proven change of the cholesterol values occurs however until approximately two weeks after the start of therapy and reaches its maximum after four to six weeks.

For the most part on the liver and the digestive tract and to a smaller extent of the kidney excretion of simvastatin via urine.

By clinical studies, it has been confirmed that simvastatin lowers the risk of deadly events such as a heart attack or a stroke in heavily.

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Price comparison

The table below shows all alternatives to simvastatin STADA 5 mg film-coated tablets: it drugs are listed, which are offered also as film-coated tablet with the drug dosage 5 mg simvastatin per film-coated tablet.
(Please note also our notes about the price and payment information)

Price comparison
Sort according to: drug pack size price per film-coated tablets price per box	-Ad-
Drug	Pack size	Price per Film-coated tablet	Cheapest price per Pack (with surcharge),(Versandkosten)
Simva TAD 5 mg	30 Film-coated tablets	0,52 EUR	15.49 EUR
Simva TAD 5 mg	50 Film-coated tablets	0.43 EUR	21.53 EUR
Simva TAD 5 mg	100 Film-coated tablets	0.31 EUR	30,89 EUR
Simvabeta 5 mg film-coated tablets	30 Film-coated tablets	0.36 EUR	10,94 EUR (5.00 EUR), price (3,95 EUR shipping) price comparison
Simvabeta 5 mg film-coated tablets	50 Film-coated tablets	0.24 EUR	11.96 EUR (5.00 EUR), price (3,95 EUR shipping) price comparison
Simvabeta 5 mg film-coated tablets	100 Film-coated tablets	0,15 EUR	Price from 14.63 EUR (5.00 EUR), (3,95 EUR shipping) price comparison
Simvacard 5 mg	30 Film-coated tablets	0.59 EUR	17,68 EUR
Simvacard 5 mg	50 Film-coated tablets	0.48 EUR	23,94 EUR
Simvacard 5 mg	100 Film-coated tablets	0.36 EUR	35,73 EUR
SimvaHEXAL 5 mg film-coated tablets	30 Film-coated tablets	0,52 EUR	15.49 EUR
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• All existing medicines containing the same active ingredient as simvastatin STADA 5 mg film-coated tablets

• Drugs containing the same active ingredient as simvastatin STADA 5 mg film-coated tablets in combination with other active ingredients

Back to the overview

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Warnings & precautions

• Usually there is no interference with the drive – to occur dizziness (rare) the driving of vehicles, but should be performed.
• Pain, weakness, and speed of the muscles occur during treatment with the drug, the doctor must be informed promptly.
• Grapefruit juice should be avoided during treatment with the drug as a result of interactions.
• Before surgery, the treatment with the drug is to interrupt.
• The dose of the drug must be reduced or stopped the treatment when the patient’s liver increase to three times of their original value.
• The dose of the drug must be reduced or stopped treatment if the CK value (characters of muscle destruction) of patients on five times of its initial value is greater.
• With breathing difficulties, cough reflex, fatigue, weight loss and fever, the treatment should be terminated.
• The product is not suitable for people with hereditary conditional Galactose intolerance (Galactose intolerance), poor glucose-Galactose recording from the digestive tract (glucose-Galactose malabsorption), as well as digestive weakness to lactose (lactase deficiency).
• In patients with an increased risk for muscle diseases (CPK levels) their blood values should are determined prior to the treatment by the doctor. In the event of muscle pain, muscle weakness or muscle cramps during the treatment of CPK levels in the blood should be determined by the doctor. The CPK values are significantly increased, the treatment should be terminated.
• Regular medical checks of liver function tests are recommended.

Medicines can cause allergic reactions. Evidence for this can be: redness, runny nose, itching, swelling of the mucous membrane, itching and redness of the eyes, narrowing of the Airways (asthma). In rare cases, there may be allergic shock with loss of consciousness.

Should you perceive signs of an allergic reaction, immediately inform a doctor.

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Interactions

What interactions of active substance of simvastatin in simvastatin STADA 5 mg film-coated tablets are known? It is important to note that the interactions can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

Simvastatin may be used at the same time with:

• Antibiotics (erythromycin, clarithromycin, telithromycin)
• Nefazodone (for depression)
• Fungal agents (ketoconazole, itraconazole)
• the funds to build muscle Danazol
• Medications for HIV (HIV-1 protease inhibitors: nelfinavir, saquinavir, ritonavir, indinavir, amprenavir).

Reason for this is that these funds and simvastatin effect on the same mechanism of metabolism in the liver. While taking simvastatin would significantly increases the concentration in the blood and significantly increased the risk of complications in skeletal muscle. Also the metabolism in the liver the antihypertensive agents of Verapamil and diltiazem, the Amiodarone employed against cardiac arrhythmias, the vitamin niacin (at doses of 1 G per day) affect the blood fat-lowering Fibrate (Bezafibrat, Gemfibrozil, Fenofibrate) and the drug Cyclosporine, omitted the body’s defenses. To reduce the risk of diseases of skeletal muscle, the following shall apply:

• Danazol, Cyclosporine, niacin and Fibrate should be taken at the same time with more than ten milligrams of simvastatin per day.
• Verapamil and especially Amiodarone should be applied with more than 20 mg simvastatin per day. Sometimes otherwise muscle wasting, subsequently even to renal failure within a so called rhabdomyolysis, sometimes fatal. Alarm are colafarbener urine and muscle pain
• Diltiazem should be applied with more than 40 milligrams of simvastatin per day.
• Grapefruit and grapefruit preparations should be waived during treatment with simvastatin completely. Grapefruit and grapefruit preparations increase the risk for complications on the skeletal muscle because they also hinder the simvastatin removal.

The blood clotting time is extended when taking simvastatin with orally taken Blutgerinnungshemmern (Cumarinen). Therefore a regular medical examination of blood clotting should be done at the beginning of therapy. Patients taking much to much alcohol to (alcohol abuse), simvastatin may apply only in particular medical care because it can cause more liver damage.

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Dosage

The film-coated tablets contain 5 mg of the active substance simvastatin. In addition, film-coated tablets the dose are available 10 mg, 20 mg and 40 mg. Several lower-dose pills together can be taken to get the desired dosage. The tablets are taken with abundant liquid whole sober in the evening or during a meal. Depending on the disorder to confidentiality, the dosage and the pace of revenue differs.

(For the treatment of lipid disorders, hypercholesterolemia) 10 mg be taken initially once a day in the evening, possibly needs a dose of 5 mg be started. The dose can be increased once a day after consulting with the doctor up to 80 milligrams. The lipid levels monitored during treatment. The desired values are achieved, the dose can be reduced again.

In coronary heart disease 20 milligrams of simvastatin be taken with treatment once daily in the evening. The dose adjustment is done in same way as in hypercholesterolemia.

The tablets can be combined with inhibitors of bile acids recovery (Anionenaustauscherharze: cholestyramine, colestipol). Taking simvastatin should two hours or four hours after taking this Anionenaustauscherharze be carried out.

While taking the blood pressure lowering agents of Verapamil and diltiazem, of Amiodarone bet against cardiac arrhythmia, of the vitamin niacin (at doses of 1 G per day) which may Danazol and of the defence oppressive drug Cyclosporine well-controlled lowering Fibrate (Gemfibrozil, Bezafibrat), the Anabolikums not more than 10 mg of simvastatin daily ingested.

The drug therapy will be supported through diet and physical activity.

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Contra-indications

The following information about contra-indications in the application of 5 mg film coated tablets in General, pregnancy & lactation, and children of simvastatin STADA. It is important to note that the contra-indications can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

When are simvastatin STADA not allowed 5 mg film-coated tablets?

The active ingredient may not be applied when:

• existing has compared to simvastatin
• acute liver disease (hepatitis)
• long-lasting boost certain liver enzyme values (increase the transaminases)
• Diseases of the skeletal muscle with muscle fiber degradation
• strong increase in skeletal muscle-specific blood values (creatine).

Simvastatin may be used at the same time with other lipid senkern (Gemfibrocil, Fibrates and niacin), with antibiotics (erythromycin, clarithromycin, telithromycin), some heart and blood pressure means (Amiodarone, Verapamil, diltiazem), certain antidepressants (nefazodone), certain fungal agents (itraconazole, ketoconazole), Immunologikum ciclosporin and certain medications for HIV (indinavir, nelfinavir, saquinavir, ritonavir, amprenavir). These agents delay the Elimination of simvastatin and increase the risk of the destruction of a muscle fiber. Only after a careful medical risk benefit simvastatin may be used due to the increased risk of a muscle fiber degradation in:

• Patients over 70 years of age
• impaired renal function
• Thyroid function
• hereditary diseases of the skeletal muscle in the family
• Muscle complaints in previous treatments from the groups of statin or Fibrate lipid senkern
• chronic alcohol abuse.

What must you consider when pregnancy and breast-feeding?

It is not sufficiently clear whether simvastatin caused a special threat to the unborn child. Damage to the unborn were observed in animal studies. The use of simvastatin in pregnancy should be performed because the benefit does not justify the risk. Existing fertility or the absence of preventive measures, you should stop taking of simvastatin.

It is unclear whether the drug in breast milk is over. In lactation, simvastatin may not be applied.

The temporary discontinuation of the drug does not affect the success of a duration of therapy.

What is taken into account in children?

Currently, an application in children and adolescents under 18 years of age is not recommended because the safety still not demonstrated of simvastatin.

Developer: STADApharm GmbH
Active ingredient: Simvastatin

prescription required-standard free

Side effects

What side effects can the active ingredient simvastatin in simvastatin STADA have 5 mg film-coated tablets? In the following, you learn the most important thing possible, well-known side effects of simvastatin in simvastatin STADA 5 mg film-coated tablets. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the drug form of the drug (for example, Tablet, syringe, ointment).

Uncommon side effects: strong liver enzyme increase in value, more than the triple value (transaminases).

Rare side effects: headache; Anaemia; Numbness (in legs and arms); Dizziness; Nausea and vomiting; Diarrhea; Digestive disorders; Constipation; Abdominal pain; Bloating; Pancreatitis; Diseases of the muscle (myopathy); Muscle pain (myalgia); Muscle weakness; Muscle destruction; Muscle spasms; Itching; Skin rash; Inflammation of the liver (hepatitis); Jaundice; ongoing liver enzyme appreciation (transaminases, alkaline phosphatase, gamma-GT); Weakness; Powerlessness; Hair loss (alopecia); Hypersensitivity reactions; Fever; Facial rötungen; Swelling of the face (angioneurotic oedema); Arthritis; Joint pain; general feeling of illness; Difficulty in breathing; Acceleration of sedimentation value; Hives; Gefäßentzündungen; Skin photosensitivity; Facial lesions (Dermatomyositis); Leukocyte disorders (platelets lack, Eosinophilic excess); Blood creatine increase in value.

Specialties: an adverse effect on the nerve seems all representatives of the statin drug group together, showing especially on the legs. The sign is numbness, burning sensations of the electron, or muscle spasms. When such symptoms, treatment with a Statin is to exit immediately. Diabetics are particularly at risk because the doctor often assigns the described symptoms of nerve damage by diabetes (diabetic neuropathy) and the offending Stastin is not used.

Further, all Statins common side effects such as insomnia, memory loss, sexual disorders, depression and damage to the alveoli (interstitial lung disease), can occur even with simvastatin.

The common use of Statins with Cyclosporine can lead to severe cases of rhabdomyolysis muscle disease. Coadministration of active substances is unavoidable, the Statins must be dosed weaker by the doctor.