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Hans Adolf Krebs

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Hans Adolf Krebs (August 25, 1900 in Hildesheim, Germany - November 22, 1981 in Oxford, England) is a German, winner of half of the work of Physiology or medicine, 1953.

Biography

Hans Adolf Krebs is the son of Georg Krebs, ENT doctor, and Alma Krebs, née Davidson. He attended the lycée pers in Hildesheim before courses of faculties of medicine at the universities of Göttingen, Freiburg in Breisgau and Berlin. He submits his doctoral thesis in 1925 at the last University where he also studied chemistry for a year. In 1926 he obtained a position of assistant to the Professor Otto Warburg at the Kaiser-Wilhelm Institute of Berlin Dalhem.

He left his position in 1930 and returned to the hospital environment, first at the municipal hospital of Altona under the direction of the Pr. L Lichtwitz, then at the medical clinic of the University of Freiburg in Breisgau under the direction of Prof. Thannhauser.

The arrival of the nazis to power in 1933 him to lose his place and he went to the school of Biochemistry, Cambridge at the invitation of Frederick Gowland Hopkins, winner of the half of the work in Physiology or medicine in 1929. He left Cambridge for the position of lecturer at the Faculty of pharmacy of Sheffield in 1935. In 1938, he became the Director of the newly founded Department of biochemistry. He obtained the rank of Professor in 1945 and became a unit of research in a medical research Council that is created. This structure is transferred to Oxford in 1954.

Krebs research mainly concerned various aspects of intermediary metabolism. He studied the synthesis of urea in the liver of mammals, the synthesis of uric acid and bases of purine in birds, the intermediate steps of the oxidation of food products, the mechanism of the active transport of electrolytes and the relationship between cellular respiration and the generation of adenosine Polyphosphate.

He has written several articles, including the remarkable study on transformations of energy in life, published in 1957, in collaboration with h. l. Kornberg, who discussed the complex chemical processes that provide living organisms phosphate by the Krebs cycle.

Krebs was elected President of the Royal Society in London in 1947. In 1953, it is winner of half of the Nobel Prize in Physiology or Medicine (the other half was awarded to Fritz Albert Lipmann) “for his discovery of the citric acid cycle” (Krebs cycle). In 1954, he received the Medal of the Royal Society and, in 1958, the Gold Medal of the society of the Netherlands for physics, medical science. It was CBE in 1958. He holds honorary titles of the universities of Chicago, Freiburg-im-Breisgau, Paris, Glasgow, London, Sheffield, Leicester, Berlin (Humboldt) and Jerusalem.

He married Margaret Cicely Fieldhouse, of Wickersley, Yorkshire, in 1938. They have two sons, Paul and John, and a daughter, Hélène.

 


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