Chlorpromazine

In Drug by Sylvie Forestier Views: 6

General

Chlorpromazine is used for psychotic disorders, especially when strong agitation or excitement. The patients calm after drug, aggression will be dismantled and normal sleep cycle. The active ingredient of chlorpromazine is often used also for the treatment of Manias (pathologically increased mood) or manic syndrome.

Is this ingredient for what purposes?

• Reduce psychotic disorders
• Promote sleep
• Reassure patients
• Inhibit vomiting
• Reduce aggression
• Relieve hiccups
• counteract pathologically increased moods

So does chlorpromazine

Learn more about the applications and the action of chlorpromazine below. Read also the information about the active group of antipsychotic drugs to which belongs the active ingredient chlorpromazine.

Fields of application of the active substance: chlorpromazine

Chlorpromazine is used for psychotic disorders, especially when strong agitation or excitement. The patients calm after drug, aggression will be dismantled and normal sleep cycle. The active ingredient of chlorpromazine is often used also for the treatment of Manias (pathologically increased mood) or manic syndrome.

Continue to chlorpromazine occurs when severe bouts of hiccups the application, provided that here the calming effect of the active substance is no discordant.

As the second choice it can be used for vomiting with a cause in the central nervous system.

Mode of action of chlorpromazine

Chlorpromazine is referred to as a prototype of the subgroup of phenothiazines from the area of antipsychotic drugs. It blocks the dopamine-docking stations in the central nervous system like other Neuroleptics. In addition to the binding authorities blockade, also the release and transfer of dopamine is inhibited. This leads to a sedative and antipsychotic effect. Also the relief of emesis can be explained about the blockade of the binding sites.

In addition, chlorpromazine inhibits the peripheral effects of Catecholamines (messengers for the heart) very much. This produces a reduction of drive. To normalize pathologically increased mood States, and abnormal excitement. A drop in blood pressure and lowering the body temperature of the decoupling of the thermoregulation in the brain can also be observed.

In addition, chlorpromazine has also an inhibitory effect on other body’s messengers, such as, for example, acetylcholine and histamine, or their docking stations (receptors). To signify the many undesirable side effects.

Warnings and precautions

• ECG changes can occur.
• Regular liver and kidney value checks are required.
• Caution in asthmatics.
• A check of the thyroid hormone in long-term use is necessary.
• Regular blood count checks are recommended.
• A review of the value of potassium in the blood is required.
• There is the possibility of epileptic seizures increase of epileptic readiness.
• A decreased responsiveness can occur.
• Difficulties may be encountered during urination.
• The auto-focus marriages can be reduced.
• Be careful when using machines.
• One drawback to active participation in road transport is possible.

Remedy ingredients sometimes trigger allergic reactions. Should you perceive signs of an allergic reaction, so you tell your doctor or pharmacist promptly.

What side effects can chlorpromazine have?

Below, you will learn the most important thing possible, well-known side effects of chlorpromazine. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

Very common side effects: dry mouth, acceleration of the heart rate, low blood pressure, fatigue, feeling a stuffy nose, difficulty in the sharp vision of objects, constipation, urinating, strong blood pressure waste when set up, setting up and standing up, increase in appetite, weight gain.

Common side effects: jaundice, liver enzyme increase, excitation conduction abnormalities, increases pressure, parkinson-like symptoms, errors of the movement, cycle disturbances of menstruation, breast formation in men, lactation of breast, allergic skin reactions, increase in light sensitivity, decreased power, gemindertes pleasure.

Uncommon side effects: decreased number of white blood cells, degradation of blood platelets, Pancytopenia (decrease all cells), boost a subset of white blood cells, inhibition of insulin excretion, boost the blood glucose, thyroid function, drug storage in lens and cornea after prolonged administration.

Rare side effects: malignant reduction of a subset of white blood cells, priapism.

Very rare side effects and individual cases: Changes of ECG, vein, Beckenvenenthrombosen.

Contra-indications

The following information about contra-indications for the purposes of chlorpromazine in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

When chlorpromazine cannot use?

Chlorpromazine should be established with hypersensitivity to the active substance or related substances.

Severe and acute liver diseases, Central conditional consciousness and Blutzell-or bone marrow damage of considerable extent should be avoided also treatment with chlorpromazine. The same applies when acute poisoning by analgesics or sedatives and psychoactive drugs and alcohol. Chlorpromazine may be used only under strict medical assessment of the risk benefit in patients with heart disease, low blood pressure, epilepsy (seizure disorders), Parkinson’s disease, liver and/or kidney deficiency, chronic respiratory problems and Elevated intraocular pressure (green star). Regular monitoring is necessary in these patients. The same applies to patients with an underActive of thyroid, diabetes mellitus (diabetes), prolactin-dependent tumors (prolactin is a hormone that regulates the development of the mammary gland and the lactation) and an enlarged prostate (prostate). The doctor will individually decide on a treatment in these cases.

What must you consider when pregnancy and breast-feeding?

In the first two-thirds of pregnancy, chlorpromazine should be administered only after careful medical assessment of the risk / benefit ratio. In the last third, completely is discouraged by a mission. Breastfeeding women should also be treated not containing this active substance.

What is taken into account in children?

Chlorpromazine is used in children usually only for the treatment of vomiting at a dose of 0.2 to 0.5 milligrams per kilogram of body weight.

What interactions shows chlorpromazine?

It is important to note that the interactions can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

The effect of Chlorpromazins is amplified in combination with painkillers, pills and tranquilizers and alcohol. It must be paid at the dosage.

Funds supporting dopamine (Parkinson’s medium) like amantadine and levodopa can in effect be watered down. Similarly, with agents against diabetes, such as tolbutamide, glibenclamide and with the antihypertensive drug Guanethidine. The other blood pressure lowering effect can be reinforced but. The doses must be customized by the attending physician.

Anaesthetics increase the hypotensive effect of chlorpromazine. This is to consider about narcosis. A careful monitoring of the circuit is urgently needed.

The active ingredients of Reserpine (blood pressure lowering effect) and disulfiram (used in the treatment of alcohol withdrawal) strengthen central and antihypertensive effects of chlorpromazine. Again, a regular circuit control is necessary.

Simultaneous use with the painkillers Metamizole, body temperature can plummet. The combined administration of metoclopramide (relieves vomiting) increases the risk of movement disorders. On these side effects must be respected especially.

Aluminium-containing active ingredients for the de-acidification as well as coffee and tea provide a reduced intake of chlorpromazine. A concomitant intake should therefore be avoided.

Smoke, the gift of lithium (used for depressive or pathologically increased moods), and antidepressants lead to a lower concentration in the blood. These resources, as well as also opioids (pain killers with morphine-like effect) be mined slowed simultaneous use. This is taken into account when the dosing intervals.

In conjunction with Metrizamid (contrast medium) increases the risk of seizure and the krampf-promoting effect of certain drugs. Careful monitoring of patients is required.

Simultaneous use of active substances which inhibit the production of thyroid hormone, increases the risk of agranulocytosis. This is a profound reduction in a subset of white blood cells. Therefore, regular blood count checks are recommended.

By simultaneous treatment with medicinal products which can change the ECG, such as chlorpromazine, as for example drugs against arrhythmia, antibiotics, malaria funds as well as other reassuring or sleep-promoting-acting drugs is strongly discouraged. The same is true with drugs that reduce the concentration of potassium in the blood (including Entwässerungsmittel), histamine gegenspielern and tricyclic antidepressants.